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Home / Services & Specialities / Gastroenterology / Colonoscopy 4 Liter (GoLytely/PEG) Split Prep Instructions

Colonoscopy 4 Liter (GoLytely/PEG) Split Prep Instructions

Colonoscopy: 4 Liter Split Colonoscopy Preparation Using GoLytely/PEG

Download a copy of these instructions here.

PLEASE FOLLOW ALL INSTRUCTIONS: Please complete the prep as directed. An incomplete prep can lead to a poor exam. Please avoid red, blue and purple liquids and soy products and juices with pulp or sediment. If you are experiencing vomiting repeatedly (more than twice) please take a 30 minute break, drink warm liquids, walk around and slowly resume your prep.


Avoid raw fruits and vegetables, cooked corn, salad, red meat, beets, nuts, seeds and granola. Multivitamins containing iron.

At least two days before the test you will need to obtain the following from your pharmacy:

  • Four (4) bisacodyl 5 mg tablets, available over the counter
  • NuLytely/GoLytely/Colyte/PEG-3350, available by prescription
  • Four (4) Simethicone pills (125 mg) over the counter


Clear liquid diet:

Clear liquids such as water, seltzer, tea or coffee (without milk or non-dairy creamer), Gatorade, broth, clear/non-citrus fruit juice, Popsicles, Jell-O. Avoid any red, blue or purple dye in Gatorade, Popsicles and Jell-O. Drink at least 64 ounces of clear liquid.


  • Take all four bisacodyl tablets with at least 8 ounces of clear liquid.
  • Take 2 Simethicone pills
  • Continue drinking clear liquids all day.

AT 4 P.M.:

Begin drinking 2 liters of NuLytely/GoLytely by drinking 8 ounces every 10 to 15 minutes. It will take you 90 minutes to 2 hours to drink the 2 liters. If the taste is objectionable, sip Fresca or other clear citrus beverage between mouthfuls of NuLytely/GoLytely. Please do not dilute prep with juice. You can add crystal light powder for taste.

AT 10 P.M.:

  • Drink remaining 2 liters of prep. It will take you 90 minutes to 2 hours to drink the 2 liter
  • Once finished drinking prep take remaining 2 Simethicone pills.


Nothing by mouth, not even gum, candy or water.

YOU MUST HAVE A RIDE HOME. You will not be discharged from the Endoscopy Unit unless you are accompanied by a responsible adult who will either drive you home or accompany you home by taxi, Uber or bus.

DIABETICS: No short acting insulin the day of your colonoscopy. Do not take any oral diabetic medications the morning of your colonoscopy. If you take anticoagulants, blood thinners or iron supplements, these must be stopped before your procedure. Please check with your physician.


Download a copy of these instructions here.

Tuyyab Hassan, MD; Ruby Malik, MD; Bushra Zia, MD; April Bowers, NP; Jeanne McCarthy, PA-C; and Lucyna Nigro, CNP
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